الفهرس 
PATHO-PHYSIOLOGY OF SICKLE CELL DISEASEOnly 14 pages are availabe for public view
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Abstract
The acute chest syndrome is a common form of lung injury in sickle cell disease . When severe , this syndrome is analogous to the acute respiratory distress syndrome . The acute chest syndrome is the second common cause of hospitalization among patients with sickle cell disease and the leading cause of admission to an intensive care unit and premature death.
The risk for developing an ACS episode appears to be increased following surgery, with an average to the development of ACS of 3 days post surgery.
Research centered around NO biology has led to an expanded understanding of the critical interdependence of NO , hemoglobin , and the microvasculature , with possible therapeutic implications for sickle cell anemia and the acute chest syndrome .
The perioperative period can offer a unique insight into the origins of acute and chronic complications of sickle cell disease . An examination of the assumptions and consequences of anaesthetic practice aimed at the prevention and treatment of these complications , similarly can provide a useful distillation of management principles .