الفهرس 
Introduction and Aim of the workOnly 14 pages are availabe for public view
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Abstract
The prevalence of Metabolic Syndrome increases with age and varies with ethnicity and race. Moreover, a plateau is reached earlier in men than women: while males onwards of 50 years of age reach a plateau of highest prevalence, females, exhibiting a steep rise after menopause, reach the highest prevalence past age 60 years.
The Metabolic Syndrome can be thought of as multiple, interrelated risk factors of metabolic origin that appear to directly promote the development of atherosclerotic CVD and is strongly associated with T2DM. (Lau et al., 2009)2 (Grundy et al., 2005)3.
Aim of our work is to explore the relationship between serum thyrotropin and BMP-4 as marker for metabolic syndrome in comparison to type 2 Diabetes Mellitus and normal population.
Our study was conducted on 50 subjects selected from the inpatient & outpatient clinic of internal medicine department of Beni Suief University hospitals from September 2011 to January 2012.
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They were divided into the following groups: Group A: 20 subjects with Metabolic Syndrome. Group B: 20 subjects with type 2 diabetes Mellitus Group C: 10 healthy subjects as control.
The results were statistically analyzed and we observed the following:
Regards BMI, there was a high statistical significant difference among the studied groups being higher in group A (m= 41.4+4) than group B (m= 38.5+5), than group C (m= 29.5+5), (p-value < 0.01). (Table No. 10).
Regards WC, there was a high statistical significant difference among the studied groups being higher in group B (m= 123+14) than group A (m= 119+9), than group C (m= 98+14), (p-value < 0.01). (Table No. 10).
As regards WHR, there was a high statistical significant difference among the studied groups being higher in group B (m= 1.9+0.2) than group C (m= 1.5+0.4), than group A (m= 1.1+0.5), (p-value < 0.01). (Table No. 10).
As regards Cholesterol level there was no statistical significant difference between the studied groups being higher in group B (m=197+35) than group A (m=195+30) followed by group C (m=178+30) (p-value > 0.05). (Table No. 11).
Regarding TG level there was a high statistical significant difference between the studied groups being higher in group B (m=161+55) than group A (m=127+51), followed by group C (m=87+18) (p-value < 0.01). (Table No. 11).
Regarding LDL level there was no statistical significant difference between the studied groups being higher in group A (m=125+39) than group B (m=120+31) followed by group C (m=113+31) (p-value > 0.05). (Table No. 11).
As regards HDL-C level there was a statistical significant difference between the studied groups being higher in group C (m=47.6+3) than group A (m=45+3.5) followed by group C (m=41.8+4) (p-value < 0.05). (Table No. 11).
Regarding TSH level there was a statistical significant difference between the studied groups being higher in group A (m=4.2+2) than group B (m=3.6+2), and group C (m=3.6+2) (p-value < 0.05). (Table No. 11).
As regards Insulin level there was no statistical significant difference between the studied groups being higher in group B (m=12+5.8) followed by group A (m=10.3+6) followed by group C (m=9.1+5) (p-value > 0.05). (Table No. 11).
Regarding HOMA level there was a statistical significant difference between the studied groups being higher in group B (m=96+30) than group A (m=40+30) followed by group C (m=34.8+20) (p-value < 0.05). (Table No. 11).
As regards BMP-4 level there was a statistical significant difference between the studied groups being higher in group B (m=1108+780) followed by group A (m=710+490) followed by group C (m=304+46) (p-value < 0.05). (Table No. 11).
The area under the ROC curve was 0.50 for serum BMP-4 levels. The observed diagnostic efficacy of serum BMP-4 levels for metabolic syndrome was moderate. The cut-off value was 80 pg/mL, the sensitivity was 79%, and the specificity was 40%.
These results were in agreement with those of (Jang-Won Son et al., 2011)258 the area under the ROC curve was 0.661 (P = 0.022, 95% CI = 0.528 to 0.794) for serum BMP-4 levels. The observed diagnostic efficacy of serum BMP-4 levels for metabolic syndrome was moderate. The cut-off value was 2.84 pg/mL, the sensitivity was 69.6%, and the specificity was 54.7%.
TSH is considered more valid predictor of metabolic syndrome compared to BMP-4. But Sensitivity and Specify are increased when used Both TSH and BMP-4.