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Abstract Postpartum period is one of the most important and critical periods of female reproductive life that determines the future fertility of the female. Any extension of the postpartum period in cows might have an important influence on the reproductive performance of the individual animal. This study aimed to 1) highlight the most common clinical forms of postpartum anestrous and 2) to investigate the effect of early interference using specific treatment for each clinical form on the postpartum reproductive performance. eighty eight cows were categorized into four groups following examination; Control, Persistent CL, smooth inactive ovaries and follicular theca cyst groups. Cows diagnosed with PCL received 250 µg/ ml Estroplan injection starting at 30 days after calving. On the other hand, 100 µg/ ml Gonabred was injected to cows either suffered from smooth inactive ovaries or follicular theca cyst at 30 days after calving. The percent of animals which were affected with PCL was significantly higher than those with smooth inactive ovaries or follicular theca cyst. Days to first bred was found to be higher in PCL group than in smooth inactive ovaries and follicular theca cyst groups. On the other hand, the average days open was higher in smooth inactive ovaries group than follicular theca cyst and persistent corpus luteum groups. The number of services per conception was significantly higher in follicular theca cyst group than persistent corpus luteum and smooth inactive ovaries groups. from this study we could conclude that: 1-Persistent corpus luteum constitutes the major part of postpartum ovarian affections causing anestrum in cattle. 2-Early interference as early as 30 days postpartum is a useful approach to improve the postpartum reproductive performance by decreasing days to first bred, days open and number of services per conception. |