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العنوان
Use Of Antenatal Corticosteroid Before Elective Cesarean Delivery Near Term Or After 34 Weeks Of Gestation
المؤلف
Amal ,El Said Ramadan Ali
هيئة الاعداد
باحث / Amal El Said Ramadan Ali
مشرف / Ashraf Fawzi Nabhan
مشرف / Amr Mohamed El Helaly
الموضوع
Pharmacology of corticosteroids-
تاريخ النشر
2010
عدد الصفحات
89.p:
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
أمراض النساء والتوليد
تاريخ الإجازة
1/1/2010
مكان الإجازة
جامعة عين شمس - كلية الطب - Obstetrics and Gynecology
الفهرس
Only 14 pages are availabe for public view

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from 89

Abstract

This study was conducted in Ain Shams University and International Mansoura Hospital.
A number of pregnant women (n= 240 cases) were admitted to the hospital to perform elective cesarean sections.
The participants were randomized to either receiving antenatal corticosteroids or no treatment.
Subgroup analysis was performed based on timing of elective C.S, whether > 37 weeks or between (34-37 weeks).
Subgroup: (n= 123) pregnant women with gestational age between (34- 37 weeks), in which (60) of them had received a single course of antenatal corticosteroid (Dexamethasone in two doses; each 12 mg, 12 hours apart by intramuscular route.
subgroup: (n= 117) pregnant women > 37 weeks of gestation, in which (60) of them had received the same course and doses of Dexamethasone by the same route of administration.
Then the delivered neonates were resuscitated and examined by using Apgar score at 1 min and 5 min of observation continued for 48 hours afterwards to detect the development of any respiratory morbidity.
The results of our study were the following:
• Regarding the total participants:
o Admission to NICU 0.75 (0.4-1.39), risk of RDS 0.8 (0.32-1.9), risk of TTN was 0.7 (0.2-1.7), risk of mechanical ventilation was 0.9 (0.3-2.14), incidence of other respiratory complications 0.7 (0.17-3.28), incidence of non respiratory complications was not estimatable, incidence of neonatal death was also not estimatable, also it was found that the risk of readmission to NICU was 1 (0.2-6.9) and risk of post partum febrile morbidity was 1.8 (0.7-4.5).
• Regarding subgroup analysis:
 Regarding participants between (34-37 weeks of gestation):
o Admission to NICU 0.5 (0.2-1.03), risk of RDS 0.6 (0.2-1.6), risk of TTN 0.2 (0.05-1.2), need to mechanical ventilation 0.6 (0.2-1.6), incidence of other respiratory complication 0.6 (0.1-3.6), risk of non respiratory complications was not estimatable as it was 0% in intervention also neonatal death and readmission to NICU were also not estimatable, lastly it was found that risk of postpartum febrile morbidity was 4.2 (0.9-19).
 Regarding participants between (>37 weeks) of gestation:
o Admission to NICU risk was 1.8 (0.5-5.9), risk of RDS was 2.1 (0.2-22.5), risk of TTN 1.7 (0.4-7), risk of need to mechanical ventilation 3.1 (0.3-29.4), incidence of other respiratory complications 1 (0.06-16.4), non respiratory complications was not estimatable as there were no cases. Also neonatal death and readmission to NICU were not estimatable, even though the risk of post partum febrile morbidity was 0.8 (0.2-2.9).