الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 247 |  |  |
| | | from | 247 | | |
Abstract
Vit.D has been recently found to be associated with many metabolic disorders as obesity and diabetes.The present work aims to study vit.D and adipokines status in type 2 diabetic females with different body weights and to investigate the probable correlation between serum vit.D level and two of adipokines namely adiponectin and resistin.The study involved 72 females, 36 non diabetic and 36 diabetic, divided into 3 groups according to their body mass index.Biochemical assays for vit.D,resistin,adiponectin and many other parameters were done and vit.D deficient persons have received vit.D replacement therapy.Results showed that vit.D was deficient in morbid obese non diabetic and morbid obese diabetic females.Adiponectin was significantly reduced in obese and morbid obese non diabetic females and in normal weight diabetic females.Resistin was significantly reduced in obese and morbid obese diabetic and non diabetic females and in obese diabetic females.Vit.D replacement therapy improved insulin sensitivity in diabetic females but didn’t affect adipokine dysregulation.Conclusion is that vit.D deficiency is an important finding in morbid obese non diabetic and morbid obese diabetic females suggesting a possible protective effect for vitamin D against obesity and type 2 DM.