الفهرس 
Blood collection and blodd processingOnly 14 pages are availabe for public view
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Abstract
The present work was planned to determine the levels of CoQ10 in some food items , and investigate its adminstration biologically as antioxidant on oxidative status of hyperlipidemic rats as well as the biochemical and microscopical changes in comparison with the healthy rats . The results revealed that:
from the results it was clear that cow beef, mackerel fish, peanuts, sesame seeds and spinach were the main rich food sources of CoQ10, the levels were being 2.89±0.85 , 2.67±0.50 , 2.66±0.83, 2.33±0.45 and 2.3±0.43 mg% respectively . Followed by chicken , soybean oil and corn oil , the levels were being 1.56±0.61, 2.00±0.65 and 1.80±0.49 mg% respectively .
Male adult albino rats (n=64) were classified into healthy and hyperlipidemic rats that fed on either balanced or HF-HC diet with and without CoQ10 at the tested dose of 90 mg/kg diet.
The results of lipids profile were significantly decreased except HDL-C in case of healthy rats fed on HF-HC diet plus CoQ10. The values decreased by about 6.76%, 11.31%, 9.07%, 9.08% and 20.83% for TL, TC, TAG, VLDL-C and LDL-C respectively compared to healthy group fed on HF-HC diet without CoQ10. As well as the values of lipids profile significantly decreased except HDL-C in case of hyperlipidemic rats maintained on either balanced or HF-HC diets supplemented with CoQ10. Also,CoQ10 significantly decrease serum MDA, while significantly increase erythrocyte SOD, hepatic CAT and reduced GSH in case of healthy rats fed on HF-HC diet, and hyperlipidemic rats fed on either balanced or HF-HC diets. CoQ10 caused a significant decrease in serum enzymes transferases activities (AST, ALT) in case of healthy rats fed on HF-HC diet, and caused a highly significant decrease in case of hyperlipidemic rats fed on either balanced (50.11±2.08 U/L for AST and 44.07±3.40 U/L for ALT) or HF-HC diet by about 12.59% (AST) and 7.17% (ALT). On the other hand CoQ10 significantly decreased hepatic TL and TC by about 7.81% and 11.30% respectively in case of hyperlipidemic rats fed on balanced diet and by about 5.08% and 16.19% respectively in case of that fed on HF-HC diet in comparison with untreated groups. Microscopical examination of liver section of healthy rats maintained on HF-HC diet showed focal mononuclear inflammatory leucocytes cells infiltration in the myocardium, while showed dilatation of portal and central vein in case of healthy rats fed on HF-HC diet plus CoQ10.The liver section of hyperlipidemic rats maintained on balanced diet showed Kupffer cells, fatty degeneration and pyknosis.While showed mononuclear leucocytes inflammatory cells in case of hyperlipidemic rats maintained on balanced diet plus CoQ10 and pyknosis and karyomegaly in case of that fed on HF-HC diet plus CoQ10.