الفهرس 
PATHOPHYSIOLOGY OF NEUROLOGICAL COMPLICATIONSOnly 14 pages are availabe for public view
 |  | from | 106 |  |  |
| | | from | 106 | | |
Abstract
Liver transplantation (LT) is the only radical treatment for end-stage
liver disease. Due to increased safety and logistic facilities, the number of
transplanted patients is continuously increasing. The increased frequency of
this procedure justifies a great effort to reduce post-transplant complications,
since these may have major impact on both survival and quality of life. Of all
the complications of liver transplantation, the neurological ones are
particularly relevant, since they affect about 13-47% of transplanted patients,
causing significant mortality and morbidity.
Neurological complications (NCs) following liver transplantation are
due to: metabolic complications, profound cerebral and systemic
hemodynamic alterations, brain hypoperfusion, cerebral hemorrhage,
anterior spinal artery syndrome, central nervous system (CNS) infections,
CNS neoplasms and Immunosuppressant neurotoxicity.
Neurological complications can be classified according to the severity
and the time of occurrence into: minor versus major complications, surgery
related complications versus post-surgical complications. The latter can be
distinguished as: early (within 1 month after surgery) and late complications.
Minor complications include: tremors, headache, sleep disorders and
peripheral neuropathy, while major complications include: encephalopathy,
seizures, cerebrovascular complications, cerebellar syndrome, posterior
reversible encephalopathy (PRES) syndrome, central pontine myelinolysis
(CPM) syndrome, focal neurological deficits and akinetic mutism. Late post