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Abstract Hyperglycemia is frequently found in critically ill patients even in the absence of diabetes and it is associated with a poor prognosis. Over the short term, hyperglycemia can adversely affect fluid balance and immune function, and it can promote inflammation. Hyperglycemia negatively affects many body systems, including the cardiovascular (acute myocardial ischemia, cardiogenic shock, arrhythmias), neuromuscular (polyneuropathy), immunologic (immunosuppression, nosocomial infections) and cerebral (ischemic stroke), and also impairs wound healing. Complication of both diabetes and critical illness are explained by hyperglycemia and /or lack of insulin , but additional factors ( Hypoxia/ reperfusion, GLUT-1, GLUT-3,inducible nitric oxide synthase (iNOS), cytokines, etc ) render both of these effects more acutely toxic in critically ill patients. |