الفهرس 
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Abstract
In the present study Hundred twenty male Balb/c mice (2–3 months old) were equally divided into 6 groups. Gp. (1) was the control. Gp. (2) (experimental control) given olive oil intraperitoneally at a dose of 0.4 ml/kg, twice a week for 6 weeks Gp. (3) (experimental control for taurine) was given Taurine (additional 2% taurine (w/w) added to a standard chow) for 6 weeks. Gp. (4) was given CCl4 intraperitoneally (i.p.) at a dose of 0.4 ml/kg, dissolved in olive oil, twice a week for 6 weeks, for development of hepatic fibrosis. Gp. (5) (protective group) was given CCl4 (0.4 ml/kg) and taurine (2% (w/w) added to a standard chow) for 6 weeks followed by taurine alone for 2 weeks. Gp. (6) (therapeutic group) was given taurine (2% taurine (w/w) added to a standard chow) for 2 weeks after completion of the 6-week CCl4 treatment.
The histopathological findings, immunohistochemistry and TEM, were used to evaluate the antifibrotic effects of taurine on the hepatic fibrosis induced by CCl4. That revealed low grade liver fibrosis, improve of both HE picture ultrastructure of liver with less Fibrillar collagen deposition and decreased expression of α-SMA positive HSC in gps (5 and 6) more than gp (4), especially in gp (5).
Conclusion: It could be concluded that Taurine (antioxidant, and antifibrotic) protected against the CCl4 induced hepatic fibrosis and treated it. Taurine is recommended for protection against the hepatic fibrosis.