الفهرس 
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Abstract
The aim of the present study was to demonstrate the uterine reactivity in experimentally-induced hyperuricemic rats.Thirty adult non-pregnant female albino rats of local strain weighing 140-180 grams were used in this study. Rats were divided into the following three groups:Group I: Control group (10 rats).Group II: Hyperuricemic group (10 rats).Group III: Hyperuricemic allopurinol-treated group (10 rats).In each of previously mentioned groups: serum UA, serum urea, serum creatinine, plasma MDA, erythrocyte SOD activity and systolic blood pressure were estimated. Isotonic spontaneous uterine contractility and uterine reactivity to Ach and oxytocin were recorded in the estrous phase.The results showed that administration of oxonic acid potassium salt in a dose of 250 mg/Kg body weight, i.p. daily for 4 weeks resulted in statistically significant increase in the mean values of serum UA, plasma MDA and systolic blood pressure and significant decrease in the mean value of SOD activity, but insignificant change in the mean values of serum urea and creatinine when compared to the corresponding mean values in the control group. However, the spontaneous uterine contractions and uterine reactivity to either of oxytocin or Ach showed insignificant change when compared to the corresponding mean values in the control group.
In hyperuricemic allopurinol-treated group, concurrent administration of allopurinol (5mg/kg orally) with oxonic acid potassium78salt daily for 4 weeks, caused statistically significant decrease in the mean values of serum UA, plasma MDA and systolic blood pressure but, insignificant change of the mean values of serum urea & creatinine, SOD activity, spontaneous uterine contrations and the uterine reactivity to either of oxytocin or Ach when compared to the corresponding mean values in the hyperuricemic group.