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Abstract
Title: Assessment of the Corrective Role of Ascorbic acid (Vitamin C) on Alkyl Mercury Chloride compounds induced genotoxicity in human blood lymphocyte cultures
Chemistry / Physics Department, Faculty of science, Cairo University Degree: Master of Science in Organic Chemistry, Faculty of Science, Helwan University
Mercury is a xenobiotic metal that is a highly deleterious environmental pollutant. The biotransfonnation of mercuric chloride (HgCb) into methyl mercury chloride (CH3HgCl) in aquatic environments IS well-known and humans are exposed by consumption of contaminated fish, shellfish and algae. One of the important mechanisms of mercury genotoxicity is its ability to produce free radicals that can cause DNA damage.
Ascorbic acid (AA) is a sugar acid with antioxidant properties. The L-enantiomer of ascorbic acid is commonly known as vitamin C . Ascorbic acid extremely unstable in vitro. Ascorbic acid (AA) is involved in various biological processes, including free radical scavenging, and it has been demonstrated that treatment with AA significantly reduced the genotoxicity of well-known mutagens.It reduces other radicals including the hydroxyl radical.