الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Background HCV is a leading cause of chronic liver diseases, cirrhosis and hepatocellular carcinoma. Liver fibrosis and the end-stage of liver fibrosis, ’Cirrhosis, represent the final common pathway of
virtually all chronic liver diseases. The aim of the present study is to
evaluate the role of fibrogenic seromarkers: Metalloproteinase -
1(MMP-1), Metalloproteinase -2 ( MMP-2), and Hyaluronic acid (HA) as
non invasive markers of liver fibrosis in chronic hepatitis C and to
correlate their serum levels with the stage of fibrosis assessed by
histopathological staging of liver biopsy.
Methods This study was carried out on 50 patients with evidence
of chronic hepatitis C, they were (42) male and (8) female. All cases were
selected from out patient clinic of the hepatology unit of research institute
for tropical medicine.the patients were divided according to the stage of
fibrosis into 5 groups from F0 to F4 according to metavir stage.serum.
MMP-1, MMP-2 and HA levels determined using enzyme-linked
immunosorbent assay technique.
Results There was statistical significant comparison between
studied groups and gender.There was statistical significant comparison
between studied groups and age.There was no significant correlation
between fibrogenic markers and laboratory investigations in all groups.
HA level increased significantly with progression of fibrosis and had
positive strong correlation with significant fibrosis. MMP-1and MMP-2
levels had no significant changes with progressive fibrosis.
Conclusions HA level increased significantly with progression of
fibrosis whereas Serum level of MMP-1 and MMP-2 had no statistical
significant change with progressive fibrosis..Keywords: Liver fibrosis;
Hyaluronic acid ; Metalloproteinase -1; Metalloproteinase-2.