الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Obesity is associated with an increased prevalence of asthma, especially in women, and appears to be more severe in the obese. This study aimed to determine if obese subjects have a specific asthma phenotype.
Methods: 200 consecutive asthmatic patients, completed an asthma control questionnaire, and sputum induction for differential cell count. BMI, waist circumference, waist-to-hip ratio and blood serum C-reactive protein also were measured. 200 consecutive apparently healthy obese subjects (body mass index [BMI] ≥ 30 kg/m2) underwent bronchial provocation by exercise provocation test.
Results: There is a high incidence of obesity in asthmatic patients, The association between obesity and asthma was higher in females , The score of ACQ increased with increase BMI and W.C of asthmatic patients, Induced-sputum eosinophil and neutrophil counts were similar in both groups, Blood serum C-reactive protein was higher in obese subjects than in nonobese subjects. There is a statistically significant association between increasing BMI and the presence of bronchial hyperreactivity in obese healthy group.
Conclusion: Obese people with asthma had poorer asthma control than nonobese asthmatics despite similar symptoms perception. Bronchial and systemic inflammatory characteristics and the specific pattern of pulmonary function changes suggest a different phenotype of asthma in these subjects. Apparently healthy obese persons who complain of dyspnea and wheeze should not be neglected because in a considerable percentage there is airway hyperresponsiveness.
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