الفهرس 
CONGENITAL ANOMALIESOF THE KIDNEYSOnly 14 pages are availabe for public view
 |  | from | 170 |  |  |
| | | from | 170 | | |
Abstract
Transforming growth factor beta-1 (TGF-β1) is a peptide of low
molecular weight and has pleiotropic action. In the kidneys, it stimulates
fibrogenesis through enhanced production of ECM proteins. The aim of
this study is to measure the level of TGF-β1 in serum and urine of
children with different grades of vesicoureteric reflux (VUR) and to
assess its diagnostic significance in the diagnosis of VUR. It has been
found that serum TGF-β1 level in children with VUR was significantly
higher than that in control children. In addition, serum TGF-β1 level in
children with grade IV-V VUR was significantly higher than that in
children with grade III VUR, which in turn was significantly higher than
that in children with grade II VUR. Thus, serum TGF-β1 level could be
used in the diagnosis of the VUR. In addition, serum TGF-β1 level has
also a prognostic value as it correlates well with the gradient of the VUR.
Key Words:
Transforming growth factor beta-1, Vesicoureteric reflux