الفهرس 
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Abstract
Prednisolone (PD) is a typical synthetic adrenal glucocorticoid, one of the most widely used steroidal agents for chronic inflammatory conditions such as arthritis, colitis, asthma, bronchitis, certain skin rashes and allergic or inflammatory conditions of the nose and eyes because it is eliminated fairly rapidly and is not very toxic. It has been used for the treatment of inflammatory bowel diseases (IBD). When PD is orally administered, a large amount of the drug is absorbed from upper gastrointestinal (GI) tracts and enters into the systemic circulation. This deteriorates the therapeutic efficacy of prednisolone and causes systemic side effects, such as adrenosuppression, hypotension and osteoporosis
(Bas it, 2005).
Therefore, this work has been made to deliver prednisolone specifically to the colon using different approaches. This may reduce frequent large doses of prednisolone and minimize its side effects.