الفهرس 
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Abstract
This chapter includes an overview of previous researches for
complexes of guanidine ligands and their application
II- Aim of the work
The work aimed to prepare and characterize new guanidinum
ligand and its metal complexes aiming to study their effects
in the treatment of microbial and tumor diseases
III- Experimental
This chapter contains the chemical and machines used in
Practical part of thesis as follow:
1) Preparation of the guanidine ligand and its metal complexes.
2) Characterization of the ligand and its complexes using:
Physical techniques such as molar conductance and magnetic
susceptibility
Elemental analyses (C, H, N, Cl and M).
Spectral techniques as IR, UV- Vis., 1HNMR, mass spectra
and ESR measurements.
Thermal techniques as DTA. and TGA
3) Measurement of biological activity
Chapter : 1 English summary
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iv. Results and discussion
This chapter includes characterization of the ligand and its complexes.
The ligand 2-(2-(4-carboxyphenyl)-guanidino)acetic acid was prepared as
follow:
1- Condensation of urea with chloroacetic acid (1:1) for three hours
to obtain 2-(carbamoylamino)acetic acid
2- Condensation of 2-(carbamoylamino)acetic acid with 4-
aminobenzoic acid (1:1) for three hours to give 2-(2-(4-
carboxyphenyl)- guanidino)acetic acid
The rreaction of the ligand (2-(2-(4-carboxyphenyl)guanidino)acetic acid)
with Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), Cd(II), Sr(II),
Hg(II), Ag(I), Tl(I) and UO2(II) ion gave metal complexes which had been
characterized by elemental analyses, IR, UV- Vis spectra, mass spectra, 1HNMR
spectra, magnetic moments, conductances, thermal analyses (DTA and
TGA) and ESR measurements. The IR data show that, the ligand behaves as
neutral tridentate, (2), [(H2L)3Cu2(OAc)4(H2O)2].H2O, neutral bidentate, (3),
[(H2L)Cu(OAc)2].1/2H2O, (13), [(H2L)2CuCl2(H2O)2], (17), [(H2L)Cu-
(OOSO2)(H2O)3], dibasic hexadentate, (4), [(L)Ni4(OAc)6(H2O)10].4H2O,
(5), [(L)Mn4(OAc)6(H2O)10].4H2O, (6), [(L)Co4(OAc)6(H2O)10].4H2O,
monobasic bidentate, (7), [(HL)(UO2)(OAc) (H2O)3], (12), [(HL)2Cu], (15),
[(HL)2Fe2(Cl4)(H2O)2].7H2O, (16), [(HL)2Cr2(Cl4)(H2O)2].7H2O, (21)