الفهرس 
The Challenge for Cell TherapyOnly 14 pages are availabe for public view
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Abstract
The adult heart lacks effective repair mechanisms, therefore any significant cell loss, may lead to the development of progressive heart failure. Cell therapy is emerging as novel therapeutic paradigm for myocardial repair.
Cellular therapy include several cell types, the two cell populations used most widely were a) skeletal muscle progenitor cells or myoblasts, and b) bone marrow – derived cells (BMCs) including bone marrow- derived circulating cells. Other cell types include embryonic stem cells, umbilical cord blood cells and adipose tissue – derived cells.
Embryonic stem cells have several restriction on their use:
- Ethical issue.
- Allogenic origin
- Teratoma formation.
Direct Intracoronary method is the current best method of cell delivery
Stem cells seem to have unlimited potential for repairing injured tissues derived from cardiovascular diseases. Currently, there are extended applications for stem cell therapy in angiogenesis, engineering a new heart, in animal models. In humans, so far, BM-derived mononuclear cells are widely used for ischemic heart diseases or peripheral occlusive artery disease. However, advanced applications of stem cells are limited by an uncontrolled cell fate, and heterogeneous populations in the ex vivo cell culture environment. Tremendous work needs to be done to tackle these issues. By keeping these safety issues under control, the future is still very bright for stem cell therapy , especially in the next decade.