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Abstract Laser vision correction (LVC) has grown with tremendous speed over the past decade. In addition to the choice of surface (photorefractive keratectomy, laserassisted epithelial keratectomy, epi-laser in situ keratomileusis) or lamellar (LASIK, femto-LASIK) treatments, the surgeon now has to select a laser profile for myopic, hyperopic, or astigmatic treatment. Wavefront-guided, wavefront-optimized, topography-guided and Q-factor adjusted ablation are the most advanced and frequently used profiles in current practice. Technical developments, clinical studies, and surgeon experience should help in selecting the best profile. This study characterizes distinctly the various ablation profiles with the use of comparative studies emphasizing the advantages and disadvantages of each in correlation to their outcome, safety and predictability. Thus highlighting the prudent use of the different profiles to ensure optimum optical and visual outcome of the refractive procedure. Key Words: • Optical quality • Aberrations – Higher order aberrations • Excimer laser • Laser surgery in vision correction • Wavefront • Topography • Munnerlyn´s formula • Q-factor |