الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
 |  | from | 149 |  |  |
| | | from | 149 | | |
Abstract
Androgenetic alopecia is a hereditary thinning of the hair induced by androgens in genetically susceptible men and women. This condition is also known as male pattern hair loss or common baldness in men.
The etiology of this condition involves the interaction of genetic and hormonal influences that result in changes in follicular architecture and alterations of hair growth cycle.
The onset of AGA is extremely variable, and appears to be determined by the presence of sufficient circulating androgens and the degree of genetic predisposition.
AGA is characterized by progressive, patterned hair loss from the scalp. AGA becomes a medical problem when the hair loss is subjectively viewed as excessive, premature and distressing. Clinical signs are usually milder in women and associated with diffuse thinning of the scalp hair.
Metabolic syndrome is a collection of health risks that increase the chance of developing heart disease, stroke and diabetes. It is also known as Syndrome X, insulin resistance syndrome and dysmetabolic syndrome.
Various risk factors have been included in metabolic syndrome. Factors generally accepted as being characteristic of this syndrome include abdominal obesity, atherogenic dyslipidemia, raised blood pressure, insulin resistance with or without glucose intolerance, prothrombotic state, and proinflammatory state.
AGA may be associated with several diseases as coronary heart disease, hyperinsulenimia, insulin resistance, hypertension, prostate cancer and benign prostatic hyperplasia.
The aim of this study was to investigate the possible association between AGA and MS.
One hundred patients with early-onset AGA (90 males and 10 females) and 100 age and sex-matched healthy persons serving as controls were included. They were selected from the Outpatient Clinic of Dermatology and Venereology Department in Menofiya University Hospital. Written consent forms approved by Committee of Human Rights in Research in Menoufiya University was obtained from every case and control subject.
Age of selected cases ranged from 25-60 years with a mean age of 40.09 ± 10.57 years. Age of control subjects ranged from 25-56 years with a mean age of 37.85 ± 9.48 years.
All patients were subjected to full history taking, general and dermatological examination. The Hamilton–Norwood scale for male and Ludwig classification for female were used to classify the patients into different grades of severity.
All participants were subjected to anthropometric measurements(weight, height, waist circumference), BP determination, measurement of fasting blood glucose, and lipid profile.
Positive family history was present in 97% of cases and 19% of controls with statistically significant difference between both groups.
There were so a statistically significant differences regarding mean values of body weight, waist circumference, and BMI between cases and controls. However, mean values of systolic BP (P=0.08) and diastolic BP.