الفهرس 
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Abstract
Background: Early loading of unsplinted implants with mandibular complete overdentures can become widespread, more clinical studies are needed to investigate the success of this approach.
Purpose: To evaluate the biochemical changes that occur in the supporting structures of two implants placed bilaterally in the canine region of the mandible as a result of 2 different early loading protocols (early functional loading and early progressive loading) in mandibular complete overdenture.
Materials and Methods: Twelve male completely edentulous patients participated in this study. Their ages ranged between 55 and 65 years. They were unable to adapt to their conventional prostheses and were complaining of their lower denture’s particularly in respect of retention and stability. They were supplied by maxillary conventional complete dentures and mandibular overdentures retained by two implants placed in canine regions. Patients were divided into two groups, The 1st group was rehabilitated according to early functional loading protocol while the other group was rehabilitated according to early progressive loading protocol.Ball attachments were used to retain the overdentures in both groups. Follow up observation period extended up to one year after overdentures insertion. Peri-implant supporting structures were assessed radiographically and biochemically.
Results: Statistical analysis showed a more favorable bone reaction with a statistically significant difference in marginal bone loss and glycosaminoglycans level (P ≤ 0.05) in the early progressive loading group than the early functional loading group.
Conclusion: The early progressive loading protocol yields a more predictable bone reaction and ensures better implant prognosis than the early functional loading protocol in a 1-yearimplant follow-up period.