الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Subclinical hypothyroidism refers to a state in which patients may
exhibit the symptoms of hypothyroidism. These patients also have a normal
amount circulating T3 and T4. The only abnormality is an increased TSH on
their blood work >4.50 micron IU/ml . Both seizures and antiepileptic drugs
may induce disturbances in hormonal system. PATIENTS WITH EPILEPSY ARE AT CONSIDERABLE RISK OF SUBCLINICAL
HYPOTHYROIDISM .THIS STUDY WAS PLANNED TO EVALUATE SUBCLINICAL HYPOTHYROIDISM IN EPILEPTIC PATIENTS ON ANTIEPILEPTIC DRUGS. The present study included 130 epileptic patients and 50 patients (control group age and sex matched to epileptic group) who were recruited from the outpatient clinic of neuropsychiatry department in El-Minia University hospital & Insurance hospital.Patients presented with two or more unprovoked seizure above the age of
18 years old of both sex, without any neurological or psychiatric disorder other than epilepsy with no past history of radioiodine therapy nor any surgical procedure of thyroid gland are included in our study.
ALL THE PATIENTS WERE SUBJECTED TO THE FOLLOWING: Careful history taking including seizure analysis
and antiepileptic drug intake.
Full general medical and neurological examination. Digital electroencephalogram.
Assessment of subclinical hypothyroidism by using The Clinical
Score of Subclinical Hypothyroidism.
Laboratory investigations: Such as assessment of thyroid functions
TSH, T3, T4. Assessment of lipid profile. THE RESULTS OF THE STUDY CONCLUDED THAT There was a statistical significant increase in TSH level in
epileptic patients and statistical significant increase in scoring of
symptoms and signs of hypothyroidism compared to control
group.
There was an increase in mean TSH levels, and scoring of
symptoms and signs of hypothyroidism in epileptic patients
receiving poly therapy than mono therapy.
Risk of subclinical hypothyroidism had increased in patients
receiving poly therapy than monotherapy.
Risk of subclinical hypothyroidism had increased in epileptic
patients receiving valproate monotherapy than epileptic patients
receiving carbamazepine monotherapy .
Epileptic patients with subclinical hypothyroidism has a risk of
hypercholesterolemia.
The level of TSH and the scoring of symptoms and signs of
hypothyroidism had statistically significant increased after taking
antiepileptic drugs for six months .
Sixteen % of recently diagnosed epileptic patients and after taking
antiepileptic treatment for less than 6 months had subclinical
hypothyroidism.