الفهرس 
Platelet Physiology and FunctionOnly 14 pages are availabe for public view
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Abstract
Although childhood immune thrombocytopenic purpura (ITP) is generally a benign hematological disorder, the presence of unpredictable bleeding symptoms usually impairs the quality of life of those children.
Aim: This study aimed to measure HRQL of patients with ITP in relation to disease parameters (course and duration of the disease, severity of bleeding and type of treatment and its side effects.
Patients and methods: Eighty children and adolescent suffering from ITP and 80 of their parents were recruited from Haematology Clinic, Ain Shams University Children’s Hospital, Cairo, Egypt. Full history and clinical assessment of ITP was taken from all patients. The Kid’s ITP Tool (KIT) was used to measure HRQOL of the participants and their parents. Reliability of the translated Arabic version was tested and showed good reliability of the tool before the beginning of the study.
Results: Our result revealed that Patients were frequently bothered by how his parents watching him and also about that they might need to have a bone marrow test. Meanwhile parents were most frequently worried about what will happen in the future of their child’s ITP. Generally, parents scores were significantly lower than child/proxy report scores (t=5.5, p<.001), especially among those with chronic ITP, (t=10.5, p<.001). There was a positive correlation between child/proxy scores and parent scores (r=.43, p<0.001). There was no significant correlation found between age of the patient with child/proxy report scores (r=-.01, P=.92) or parent report scores (r=.18, p=.11). Also there was no gender or socioeconomic difference regarding child/proxy report and parent report.
Patients’ with acute ITP had significantly lower mean scores than those with chronic ITP regarding both child/proxy report scores (t=-3.3, p=0.003) and parent report scores (t=-3.8, p=0.03) specifically in patients with acute non-resolved course. Longer duration of illness was correlated with higher child/proxy report scores (r=.31, p=.006), however, age of onset of illness was not correlated neither to child/proxy report nor parent report scores (r=-.03, p=.78; r.21, p=.06).
Both child/proxy report scores and parent report mean scores were significantly lower among patients with higher severity of bleeding (t=3.7, p=0.03, t=24.9, p=0.001 resp.). Also there were negative correlations between the severity of bleeding and both the child/proxy scores (r=-.21, p=.02), and parents scores as well (r=-.52, p=<.001).
Platelet count was positively correlated to parent report scores (r=.22, p=.05). There were no significant differences between child/proxy and parent reports mean scores of patients with different treatment regimens (t=.76, p=.47, t=.18, p=.84, resp).
Regression analysis revealed that only parent report scores had significant effect on child/proxy report scores (t=3.9, p<.001). Meanwhile the severity of bleeding had the highest significant effect on parent score followed by child/proxy report scores.