الفهرس 
TransplantationOnly 14 pages are availabe for public view
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Abstract
Renal transplantation is the treatment of choice for patients with
end-stage renal disease (ESRD). However, the clinical success of this
procedure remains dependent on the lifelong administration of
immunosuppressive medications. These agents have a variety of
undesirable side effects, many of which are directly related to the
agent’s efficacy at suppressing the immune system
CD8 is a cell surface glycoprotein found on most cytotoxic T
lymphocytes that mediates efficient cell-cell interactions within the
immune system. In general, the role of the CD8+ T cells is to monitor all
the cells of the body, ready to destroy any that express foreign antigen
fragments in their class I molecules.
CD20 is a non-glycosylated phosphoprotein expressed on the
surface of all mature B-cells. This gene encodes a member of the
membrane-spanning 4A gene family, it plays an important functional
role in B-cell activation, proliferation and differentiation.
This study includes 28 selected cases of renal allograft rejection
which are received at Cairo University-(Al Kasr Al Aini) pathology
department as well as a private lab in the period between 2000 and 2009
were reviewed.
Immunohistochemical staining of CD20 and CD8 was done using
the streptavidin-biotin technique. This thesis consisted of introduction,
aim of work, review of literature, material and methods used, results
illustrated by images, discussion of results, conclusions,
recommendations and list of references, together with a summary in
English and another in Arabic.
This work revealed that there was a weak positive correlation
between CD20 cells and C4d positivity and positive correlation with
CD8 and grades of rejection
We found CD8 cells didn’t correlate with any of the acute or
chronic scores, with C4d positivity, time post transplantor grade of
rejection.
Key words: Renal rejection, B lymphocytes, T lymphocytes, CD20
and CD8.