الفهرس | Only 14 pages are availabe for public view |
Abstract Nitric oxide is an inorganic molecule formed by vascular endothelial cells is now thought to be a messenger molecule that is believed to play a crucial role in various biological processes of both physiological and pathological importance. Endothelium-derived NO is critically involved in the regulation of a wide variety of vascular functions. It had been hypothesized that a deficiency of vascular NO might be involved in the accelerated atherosclerosis and dramatic cardiovascular mortality observed in patients with CRF. Superoxide dismutase is one of the antioxidant enzymes which catalyzes conversion of the superoxide anion to hydrogen peroxide and works concomitantly with hyDROPeroxide removing enzymes such as catalase and glutathione peroxidase to prevent the harmful effects of free radicals. Deficiency of SOD in cases of CRF may lead to a state of oxidative stress and contribute to cardiovascular complication. As both, NO and SOD, are related to oxidative. |