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Abstract The present study was carried out in three experiments at Fish Research Center and Nutrition and Clinical Nutrition Department, Faculty of Veterinary Medicine, Zagazig University, to investigate :- I- The effect of adding Distiller’s Dried Grains with Solubls (DDGS) as replacement for soybean meal and yellow corn with and without addition of ginseng (phytoadditive) in the diet of Nile tilapia fingerlings on (growth performance, body composition, nutrient digestibility, economic efficiency and some immunological and blood biochemical parameters). 2- The effect of dietary supplement with natural immunostimulants such as propolis extract (bee glue) and olive leaves extract in the diet of Nile tilapia fingerlings on (growth performance, body composition, nutrient digestibility, economic efficiency and some immunological and blood biochemical parameters). 3- The effect of dietary supplement with natural growth promoters as combination of essential oils mix and prebiotics and combination of synbiotic and phycophytic substance in compare with antibiotic (Oxytetracyline) in the diet of Nile tilapia fingerlings on (growth performance, body composition, nutrient digestibility, economic efficiency and some immunological and blood biochemical parameters). 5.1. Experiment 1:- This experiment was designed to evaluate the effect of adding Distiller’s Dried Grains with Soluble, DDGS (20% and 30%) as replacement 10 soybean meal and yellow corn with and without addition of ginseng, (0.1 %, lg/kg) as phytoadditives on growth performance, nutrient digestibility, some immunological parameters and economic efficiency A total of 360 Nile tilapia fingerlings with initial body weight of 18.55 ±O.91 g (mean ±SD) were |