الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
This thesis describes the utility of (E)-4-(4-acetamidophenyl)-4-oxo-but-2-enoic acid (I) as a key starting material for the preparation of a novel series of pyridazinones and thiazoles derivatives via interaction with nitrogen, sulfur andcarbon nucleophiles under Michael addition conditions and studies the antimicrobial activities of some of these compounds.