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Abstract In the treatment of prosthetic joint infection virtually every conceivable form was tried out, antibiotics alone or in combination with debridement and intraarticular lavage, reimplantation of the prosthesis in one or two stages, arthrodesis or as a last option the amputation. (77) The success rate of treatment with intravenous antibiotics is low. Treatment using intravenous antibiotics is recommended in patients with no other joint prosthesis and an inoperable situation due to systemic disorders. Repetitive debridement with intravenous antibiotics is used for the treatment of acute infection, and must be started in the first 2 weeks. One- or two-stage reimplantation procedures are the most favoured methods in the treatment of infected total-knee prosthesis. The eradication of infection and improvement of functional capacity can be obtained with these procedures. However, the infection rate after reimplantation procedures is much higher than that for primary implantations. Furthermore, the success of reimplantation procedures diminishes once patients have bone and soft-tissue loss. (108) Resection arthroplasty is suitable for low demand patients after failure of other treatments in patients with polyarticular rheumatoid arthritis. (71) Resection arthroplasty is an alternative method for the eradication of infection. The main disadvantages of these procedures are pain and instability in the knee during walking. A strong and stable lower extremity can be obtained with arthrodesis. The success of arthrodesis depends on surgical technique and sufficient bone stock for fusion. (108) Arthrodesis is indicated for infected TKA with deficient extensor mechanism and in cases with highly resistant organisms or salvage after failed treatments.(71) |