الفهرس 
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Abstract
It is estimated that about one third of all gynecological consultation are carried out for abnormal uterine bleeding, 80% of them are due to hormonal disorders, called dysfunctional uterine bleeding, the other 20% is due to organic causes.
Thyroid hormones directly influence the menstrual pattern through impact on the ovaries and indirectly through impact on SHBG, PRL and GnRH secretion and coagulation factors. Treating thyroid dysfunction can reverse menstrual abnormalities.
The aim of the current study (a cross sectional case-control study) is to evaluate the functional status of the thyroid gland in apparently euthyroid women with dysfunctional uterine bleeding. 80 female patients were recruited from out patient clinic of gynecology in Ain Shams University Maternity Hospital; they were divided into two groups according to the pattern of their menstrual cycle (study group and control group). All of the patients were subjected to written informed consent, clinical history and examination, pelvic U/S and measurement of thyroid hormones (Free T3, Free T4, and TSH). Finally, all data was statistically analyzed.
In the current study, regarding demographic data, there was higher mean age and parity among study group in comparison with control group but there was only statistical significant difference as regard parity.
Also, there was high statistical significant difference as regards mean duration of menstruation, amount of bleeding, and interval of bleeding between study and control groups.
Regarding sonographic data, there was statistical significant difference regarding uterine size, endometrial thickness between the 2 studied groups, on the other hand there was no significant difference regarding position of the uterus, adenxial masses.
In the current study, the prevalence rate of thyroid disorder among DUB patients was about (28%) of cases.
Among various types of thyroid disorders, only hypothyroidism was found to be significantly higher among cases (18%) in comparison to controls (0%); while sub clinical hypothyroidism which was 10% had no significant difference between cases and controls.
Higher percentage of abnormal thyroid functions was found among the cases who presented with menometrorrhagia (3 patients for each 5 patients).
Also, it was found that cases of DUB show lower mean freeT3, T4, and higher mean TSH comparing with control group, but the most prominent change in the thyroid hormonal profile was the decrease in T3 level which shows significant difference among two studied groups.
Among cases of DUB Group there was higher percentage of low T3 (16%), low T4 (12%), and elevated TSH (12%) compared with control group which in turn shows low T3 with a percentage (0%),low T4 with a percentage (3.3%),and elevated TSH with a percentage (0%), but the difference between both groups regarding Free T4 was not significant.
Among DUB group there was no statistical significant difference in older aged or younger aged –normal sized or enlarged sized uterus regards thyroid function abnormalities.
from the results of the present study, we can conclude that impaired thyroid function (either clinical or subclinical) may be an intimate cause of DUB. It is highly recommended to add thyroid function tests as a routine in all cases of DUB even in the absence of symptoms and signs of thyroid disorder.