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Abstract Interaction between heart and kidney involves several pathways including renal hypoperfusion, intraglomerular hemodynamic changes, decreased in renal blood flow and eGFR, neurohormonal and inflammatory activation. A consensus definition was needed to highlight the coexistence of cardiac and renal disorders and to identify the time course of heart– kidney interaction and the primacy of the organ leading to the syndrome. The classification that result from this definition is not meant to fix patients into one immovable category. Beside CRS, the interaction between heart and kidney includes also affection of circulatory system and blood vessels in form of hypertension , the pericardium and finally, the limitation or complication of some diagnostic and therapeutic tools. Contrast induced nephropathy that occur during coronary diagnostic and interventional procedures is considered an example of this limitation . |