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العنوان
Immunohistochemical expression of EGFR in
triple-negative breast cancer and its correlation
with clinicopathological characteristics of these
tumors/
الناشر
Mohammed Mahmoud Abd-Ellah Ali،
المؤلف
Mohammed Mahmoud Abd-Ellah ،Ali
هيئة الاعداد
باحث / Mohammed Mahmoud Abd-Ellah ،Ali
مشرف / Ahmed Mohamed Yehia ،El Hennawy.
مشرف / Samia Mohamed ،Gabal.
مشرف / Mostafa Samy ،Salem.
تاريخ النشر
2012.
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
علم الأورام
تاريخ الإجازة
1/1/2012
مكان الإجازة
جامعة القاهرة - كلية الطب - الباثولوجى
الفهرس
Only 14 pages are availabe for public view

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Abstract

Background:
Triple negative breast carcinomas (TNBCs) are a group of primary breast tumors
with aggressive clinical behavior that have no targeted therapy at present. EGFR
expression has recently come into focus as an index for molecular targeting
therapy. Histologic sections that included variable subtypes and grades of
TNBCs were studied by immunohistochemistry with EGFR, using a standard
avidin–biotin–peroxidase system.
Results: Twenty two cases showed variable positive reactivity for EGFR (55%
of total cases).
Conclusions: the level of EGFR expression was relatively high as most studies
stated, and agreed with most studies about the statement that EGFR expression is
associated with worse prognosis.
Key Words: Triple, negative, TNBC, EGFR.