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Abstract Vysis LSI 4q12 Tri-Color Rearrangement Probe through Fluorescent In Situ Hybridization (FISH) test has been used to estimate the c-Kit gene expression aberrations /rearrangements among the five hepatic adenocarcinomas of cancer stem cell origin cases (CK19 +ve/c-Kit +ve /CK18 +ve /CD133 +ve cases). from data analysis it has been found that the c-Kit amplification or aberrant gene patterns whether separate or combined together or combined with abnormal one tricolor gene expression are the most common aberration /rearrangement . This finding is coming with the strong and moderate immunohistochemistry expression of c-Kit and CD133 in those five hepatic adenocarcinomas of cancer stem cell origin cases (CK19 +ve/c-Kit +ve /CK18 +ve /CD133 +ve cases. Key word Primary - secondary- hepatic-ICC- Ck1-HCC- adenocarcinomas |