الفهرس 
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Abstract
Idiopathic thrombocytopenic purpura (ITP) is an acquired autoimmune disease
with many immune dysfunctions. Cytotoxic T lymphocyte antigen 4 (CTLA-4)
is a T-lymphocyte surface molecule that can down modulate and terminate
immune responses. Recently, several studies have confirmed that some
polymorphisms of this gene can influence its expression level, therefore
speculating that they might be associated with autoimmune diseases. In order to
investigate the role of the CTLA-4 gene in ITP, we investigated A49G
polymorphism of the CTLA-4 gene in 30 ITP patients and 20 healthy controls
through polymerase chain reaction (PCR)-restriction fragment length
polymorphism. No significant differences were revealed in genotypes and allele
distributions between the patients with ITP and the controls.
Keywords: CTLA-4, ITP, T lymphocyte, PCR-RFLP, Polymorphism