الفهرس 
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Abstract
This study will be single blinded randomized clinically interventional trial which will be held upon 60 ladies complaining from bacterial vaginosis who are attending the outpatient gynecologic clinic at Ain Shams University Maternity Hospital. This study was conducted to evaluate the efficacy and patient compliance of oral metronidazole versus oral pasteurized yoghurt in the treatment of BV among non pregnant women during their child bearing period.
Diagnosis of BV was based on Amsel’s criteria, defined as the presence of three out of the following four criteria:
1. Full history will be taken; a homogenous and grayish non inflammatory discharge that adheres to the vaginal walls and symptom of vulvovaginitis as itching and dysparenia.
2. Microscopic examination with the presence of clue cells.
3. PH of vaginal fluid >4,5
4. Whiff test is positive.
(Amsel et al., 1988)
Those who fulfilled the inclusion criteria (N=60) were randomly divided into two equal groups after an informed consent, full medical history taking and medical examination, each group included 30 participant.
Those participant of the first group (N=30) received oral metronidazole tablets 500 mg twice daily for one week and second group received oral pasteurized yoghurt 110 gm once daily in combination with oral placebo tablet twice daily for 30 days.
All participant were evaluated at the1st visit after 10 days from starting the treatment and the 2nd visit after 30 days from starting the treatment.
A cervicovaginal smear will be take in each follow up visit by using Ayer’s spatula smeared on glass slide and fixed on absolute alcohol then stained by Papanicolaou’s stain and examined by light Microscope. This will be done in Early Cancer Detection Unit in Ain Shams Maternity Hospital.
At the last follow up visit (i.e. after 30 days of starting treatment) all women will be subjected to:
1) History taking for symptoms which include:
- Symptoms of vulvovaginitis as:
1- Discharge includes quality, quantity, odor and colour.
2- Pruritus.
3- Dyspareunia.
- Symptoms of urinary tract infection as dysuria, frequency and urgency.
2) Clinical examination for evidence of bacterial vaginosis includes:
- Cusco examination to asses vaginal discharge.
- PH of vaginal fluid.
- Whiffe test.
3) Laboratory investigations including:
- Microscopic examination and documentation of the presence of clue cells.
For quantitative data the range, mean, standard deviations (±SD) were calculated; t test was used to compare pH, Whiff test, discharge and clue cells before and after 10days and 30 days of treatment. For qualitative data, the number and percent distribution were calculated. Fisher exact test was used as a test of significance. Significance was adopted at p > 0.05 for interpretation of results of tested of significance.
Follow up of our patients revealed that cure rate in pasteurized yoghurt treated group was 88% while in metronidazole treated group it was 53% which was statistically significant.
Relapse was higher in metronidazole treated group (4 cases accounting for 13.8%) while there was no relapse in pasteurized yoghurt treated group.
Failure of cure was higher in metronidazole treated group (10 cases accounting for 34.4%) than pasteurized yoghurt treated group (3 cases accounting for 12%) this difference was statistically significant.