الفهرس 
OsteoarthritisOnly 14 pages are availabe for public view
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Abstract
Osteoarthritis is a degenerative joint disease generally characterized by
progressive cartilage degeneration,. Stem cell therapy holds a great promise
for the repair of injured tissues and organs, including OA. The present
study aims to detect the effect of mesenchymal stem cells on osteoarthritis
in rabbits and also to detect its possible mechaism of action.. The study was
carried on 20 New Zealand White rabbits. They were divided into 6 groups
as follow: control group, phosphate Buffer group injected intra
articularly(IA) by phosphate buffer, stem cell group recieved stem cells, the
arthritis group induced by LPS, LPS & Stem cell treatment group injected
by LPS then treated after one week by stem cells (IA), LPS &stem cell
prophylactic group, rabbits were injected prophylactically by stem cells
then by LPS. The results of the present study showed significant increase
CRP and TNF-α in OA group compared to control group however when
this group is treated with MSCs there was significant decrease in these
parameters. Also, there was a significant decrease in TGFβ and CTGF in
OA group compared to control group and increased when treated with
MSCs. Histopathological results shows improve of OA after stem cell
therapy Conclusion, MSC can exert beneficial effect on OA possibly by a
paracrine mechanism through regulation of inflammatory cytokines such as
TNF-α and growth factors such as TGF-β and CTGF.
Key Words:
Mesenchymal stem cells
Osteoarthritis
Paracrine action of MSCs