الفهرس 
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Abstract
Multicomponent reactions (MCRs) by virtue of their ease of execution and generally high yields of products have attracted considerable attention from the point of view organic synthesis (Zhu, 2003; Hulme et al., 2003; Shi et al., 2008). Over the last few years, there has been a large development in the three-component reactions and great efforts to afford new and effective (MCRs) (Domling et al., 2000; Bazigir et al., 2008; Kumar et al., 2007). In addition, fused heterocycles systems like pyrazolopyridines, pyranopyrazoles and pyrazolopyridopyrimidines present interesting biological properties such as anticancer (Gsiusky et al., 1980), fungicidal (Madkour et al., 2007), bactericidal (Nasr et al., 2002) and vasodilatory activities (Ahluwalia et al., 1997). A considerable attention has been focused on the development of new methodologies to synthesize many kinds of this Nitrogen containing heterocycles (Quiroga et al., 2007; Quirogu et al., 2001). May of the previous multicomponent reactions for the synthesis of pyrazolopyridopyrimidines were based on utilizing amino pyrazole or amino pyrimidine as starting materials with the use of different catalysts,
(Quirogu et al., 2006). Aiming to synthesize these important candidates with low cost starting materials and facile tools, to prepare different fused derivatives via simple pyrazole(5-methyl-2,4-dihydro-3H-pyrazol-3-one) as starting material. Facile conversion of the pyrazolopyridines into pyrazolopyridopyrimidines has been reported. As for the multifocal nature of liver Carcinoma, the chemotherapy is the main choice for treatment the liver cancer patients, so developing new therapeutic agents becomes an urgent need for liver cancer patients. Encouraged by this information and continuation to our previous work (Mohamed et al., 2007; Mohamed et al., 2010), we have prepared in this report the formation of different derivatives of Nitrogen containing heterocycles and have evaluated their efficiency as an antihepatocellular Carcinoma.