الفهرس 
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Abstract
This study was designed to clarify the clinicopathological effect of Spirulina
platensis on alloxan induced diabetic rats. For this purpose 70 male albino rats fed
well balanced nutrition were used, rats divided into four groups GI (Control negative),
GII (Control Spirulina), GIII (Control diabetic) and GIV (Diabetic and treated with
Spirulina). Rats were bled at 0, 7th, 14th, 21st and 28th days, samples were directed to
hematological, biochemical and RT- qPCR assay for MDH RNA gene expression.
Animals were sacrificed at the end of the experiment, liver, kidney and pancreas were
used for histopathological examination. The results in GIII revealed macrocytosis,
leucocytosis with neutrophillia and lymphopenia, hyperglycemia, hyperlipidemia.
Significant elevations in liver enzymes, BUN and creatinine and reduction in proteins
and RT- qPCR assay for MDH RNA gene expression with insignificant changes in
GSH. GII exhibited insignificant changes in all parameters except significant increase
in GSH. Values of GIV showed improvement in the blood picture, glucose, liver
enzymes, kidney functions, lipid and protein profiles, GSH and MDH gene expression
if compared with other groups. Histopathological examinations showed severe
changes in GIII and improvement in GIV. The previous results clarified the
therapeutic benefits of Spirulina on diabetics.