الفهرس | Only 14 pages are availabe for public view |
Abstract Perinatal fetal distress with subsequent hypoxic ischemic encephalopathy is the leading cause for brain injury and mortality in neonates worldwide. The neuron-regenerative potential of cord blood stem cells has been proven in many experimental animal models. Hypoxia induces mobilization and activation of hemopoietic and mesenchymal stem cells. Umbilical cord is a rich source for mesenchymal stem cells that can be a potential source for autologous transplantation for tissue regeneration. This work is designed to examine the viability, cycling state and neural transdifferentiation potential of cord blood mononuclear cells in hypoxic, normoxic and preterm cord blood. Key Words: Hypoxia– Stem cells –Neural Transdifferentiation |