الفهرس 
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Abstract
Neonatal sepsis is one of the leading causes of morbidity and mortality among newborns, early recognition of sepsis in the neonate is one of the most difficult problems facing neonatologists today Blood culture is the best available test for detection of bacteria and diagnosis of sepsis. A difficulty faced by the clinician is that blood culture is also time consuming, and preliminary decisions about treatment strategy must be made before results from blood culture are available.
In this study, we examined neonatal infants, all with suspected sepsis, to identify which clinical sign is most predictive of sepsis defined by a subsequent positive blood culture. Variation by gestational age in the association of the clinical signs with sepsis was another central component of this research .CBC &CRP were included in this study to identify their diagnostic power and variability among septic full term and preterm neonates.
It Comprised 80 newborn infants (42 males and 38 females)(40 Full term and 40 Preterm) .admitted to Benha Children Hospital in the period from February 2012 to July 2012.
Patients were classified to Group 1 Includes full term newborn infants 37wks.
Group1 a Neonates with positive cultures Group1 Neonates with negative cultures Group Includes preterm newborn infants < 37wks.
Neonates with positive cultures eonates with negative cultures ll neonates were subjected to full history taking, clinical xamination and laboratory investigation included CBC, CRP and lood culture.
The study showed that premature rupture of membrane(PROM) was the most common risk factor for neonatal epsis.RD,O2need,feeding intolerance were statistically significant in ull term neonates with culture proven sepsis while bradycardia was ignificant in preterm ones.
I/T ratio>0.16, IPMNs & CRP showed statistically significance n culture proven sepsis rather than patients with negative culture
regardless the gestational age.
In our study we found that I/T ratio 0.16 was statistically ignificant in full term patient with culture proven sepsis ,while hrombocytopenia was statistically significant in preterm ones. CRP as statistically significant in full term & preterm neonates with ultures proven sepsis.In this study the premature newborn with sepsis were at greater isk for mortality & they had the worst outcome in relation to full term nes.
As regarding organism susceptibility our study found that staph as the most organism found in the blood culture. In comparing full erm with preterm neonates, staph was the commonest organism mong full term neonates, while klebseilla was predominant among reterm neonates.