الفهرس 
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Abstract
Nosocomial infections in Pediatric Intensive Care Units (PICUs) caused by multidrug-resistant bacterial organisms are increasing. Patients in the Pediatric Intensive Care Unit (PICU) are particularly susceptible to nosocomial infections in part due to the use of invasive devices and procedures in this critically ill population (Banerjee et al., 2006).
Health care workers with colonized MRSA infections present significant reservoir for transmission of the bacteria to the other workers and to the patients (Collo et al., 1994).
The aim of this study is to investigate the relationship between health care workers bacterial colonization and nosocomial infection in Pediatric intensive Care Units setting.
This study was done on health care workers in Pediatric Intensive Care Units (PICUs) including physicians, nurses and workers. through Nasal & interdigital swabs.
The results of the study showed that nasal swabs grew Coagulase Negative Staph aureus in 85.7% of the studied health care workers, while 14.3% grew MRSA. As well as 71.4% of the interdigital swabs did not show any bacterial growth, while 28.6% grew Coagulase Negative Staph aureus.
41.7% of the tested health care workers showed no growth in their nasal swabs after decolonization. After decolonization, 50% of the studied health care workers had Coagulase negative Staph aureus in their nasal swabs while 8.3% had Staph aureus with disappearance of MRSA.
There was a significant reduction in the rates of positive cultures after application of the decolonization program decreasing from 78.5% to 62.9% and the difference was statistically significant.
There was a decrease in Staphylococcal infections from 24.2% before health care worker decolonization to 2.1% after decolonization and the difference was highly statistically significant.
There was a decrease in the percentage of Staphylococcal growth in blood cultures from 59.1% out of the total positive cultures to 4.2% after decolonization and the difference was highly statistically significant.
We found that female gender and employment during of more than one year served as significant risk factors for nasal MRSA colonization.
In conclusion health care workers colonization with MRSA is related to the rate of nosocomial infection with the same organism. This leads to the fact that decolonization is mandatory to prevent this type of nosocomial infection.