الفهرس 
ANATOMYOnly 14 pages are availabe for public view
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Abstract
The Prolactinoma is the most common pituitary tumor,
accounting for 30% of all pituitary adenomas encountered in clinical
practice. from a practical standpoint, Prolactinomas can be viewed as
having one of the following biologic profiles : Microadenomas,
Macroadenoma and Aggressive phenotype.
The clinical features of prolactin secreting pituitary adenomas
are related to the endocinological consequences of sustained
hyperprolactinemia and the neurological sequelae of an expansible
sellar mass. In females, Menstrual dysfunction, and Galactorrhea. In
Males and post menopausal females the presentation is mainly due to
mass effect, loss of libido and erectile dysfunction occur in the former.
40 cases with proloactin-secreting adenome, (Prolactinoma)
were managed as follow, 6 cases with micro adenomas underwent
surgery via. trans-sphenoidal approach 2 cases presented with
apoplexy failed to improve on medical treatment & underwent
surgery.
The Remaining 32 cases were subjected to medical treatment
using dopamine agonists, six was failed to respond or were intolerant
&underwent surgery. Twenty six cases improved on medical
treatment.
First line of therapy with dopamine agonists is effective in
normalizing hyperprolactinemia and shrinking tumour size. Resection
is indicated in patients who can’t tolerate medical therapy or in whom
it fails. Surgery should also be considered in patients with micro
prolactinomas when complete tumor removal with biochemical cure in
an expected outcome. Apoplexy still a neurosurgical emergency needs
urgent trans-sphenoidal decompression.
Keywords:
• Prolactinoma
• Transphenoid
• Apoplexy
• Dopamine agonists.