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العنوان
Synthesis of some new pyrazolone derivatives of expected biological activity /
المؤلف
Amer, Amira Ismail Mohammed.
هيئة الاعداد
باحث / أميرة إسماعيل محمد عامر
مشرف / السيد محمد عفصة
مشرف / إيمان محمد كشك
مشرف / سها مصطفى عبدالمجيد
مناقش / عبده عثمان عبدالحميد
مناقش / هدى إبراهيم الديوانى
الموضوع
Pyrazolons. pyrazolone Derivatives.
تاريخ النشر
2013.
عدد الصفحات
175 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
علم البيئة
تاريخ الإجازة
25/5/2013
مكان الإجازة
جامعة المنصورة - كلية العلوم - الكيمياء
الفهرس
Only 14 pages are availabe for public view

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Abstract

The present study deals with the synthesis of some new phenolic and indolic compounds incorporating pyrazole moiety, starting from 4-arylidene-3-methyl-1-phenyl-5-pyrazolones as key starting compounds.
The material presented in this thesis is separated into two main parts.
Part I: Includes the reaction of 4- arylidenes (2a-c) with polyhydric phenols under different conditions. Mannich reaction with the 4-arylidenes to give phenolic bases.
Part II: The synthesis of some new indolic compound by treating (2a-c) with indole derivatives and antipyrine or pyrazolone derivatives.
• The chemical structures of the new compounds were supported by analytical &spectral data
• The newly synthesized compounds were screened for their antioxidant activity; have an ability to protect DNA from the induced damage by bleomycin and have ability for transformation (proliferated) blasts.