الفهرس 
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Abstract
Juvenile rheumatoid arthritis (JRA) is one of the most common rheumatic disease of children and a major cause of disability.It is characterized by an idiopathic syonvitis of peripheral joints associated with soft tissue swelling and effusion Vitamin D deficiency is associated with an exacerbation of Th1 immune response. Thus, in the last few years, the possible role of vitamin D in the pathogenesis, activity, and treatment of RA has been raised based on the results and observations of clinical and laboratorial studies.
In the present study evaluation of the serum level of vitamin D was doneby ELISA in children with JRA and correlated with the diseaseactivity. For this purpose twenty JRA patients regularly attending the pediatric allergy and immunology clinic, children hospital, AinShamsUniversity and fulfilling the American collage of rheumatology (ACR) revised classification criteria for JRA, were studied in comparison to twenty healthy subjects as normal controls.
Full history taking and clinical examination were done and joint activity score was assessed. Also, the following laboratory investigation were performed ESR, CRP, ANA, RF, S.Ca, S.ph, S.ALP and serum vitamin D by ELISA. The results of the present study showed that serum vitamin D was significantly lower among juvenile rheumatoid arthritis patients as compared to normal controls.
Serum vitamin D was significantly lower among juvenile rheumatoid arthritis patients with higher ESR level and positive CRP them those with normal levels or negative CRP.
In the present study different correlation analysis were done with serum vitamin D and proved to be significantly negative with ESR, joint activity score and S.ALP while it was significantly positive with S.Ca. in addition it had no significant negative correlation with the duration of the disease or age of the patients.