الفهرس | Only 14 pages are availabe for public view |
Abstract Renal transplantation is the best form of renal replacement therapy for patients with end stage renal disease (ESRD), in comparison to dialysis, as it is associated with higher patient survivals, lower hospitalization rate and a superior quality of life. Hepatitis C virus infection is an important consideration in kidney transplantation candidates and graft recipients. Mortality rates are higher among kidney transplant recipients who are positive for HCV antibodies (anti-HCV), have higher rates of liver complications and have lower survival rates after transplantation than anti-HCV–negative recipients. HCV-positive renal allograft recipients have lower graft survival duration and higher rate of infections when compared with HCV-negative renal transplant patients. NKT cells represent a heterogeneous group of immunoregulatory and effector cells, which express both NK and T-cell markers. They may protect against infection through their cytolytic activity by producing cytokines or via stimulation of other cell populations So, the aim of the present study is to assess the possible effect of HCV infection on the level of the peripheral blood NK CD 3+ and CD16+ in renal allograft recipients and their association with intercurrent infection. |