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Abstract • Estimation of Homocysteine in maternal plasma in early pregnancy did not increase the prediction of preeclampsia when added to resistance index (RI) of the uterine arteries. • Increased impedance to flow in the uterine arteries in low-risk pregnancies is associated with increased risk for subsequent development of pre-eclampsia. • Women with normal resistance index (< 0,58 ) of the uterine arteries did not develop preeclampsia. • Increased resistance index (> 0,58 ) of the uterine arteries at 24 weeks of gestation was found in about 5% of pregnancies attending for routine antenatal care. • Increased resistance index (> 0,58 ) of the uterine arteries in pregnancies attending for routine antenatal care identify about 50% of those that subsequently developed pre-eclampsia. |