الفهرس | Only 14 pages are availabe for public view |
Abstract This study was designed primarily to evaluate impact of fetal lead exposure as reflected by maternal and cord blood lead levels, on cord blood IGF-1 concentration and anthropometric measures at birth in term neonates. The study included 50 randomly selected mothers, and their newborns, recruited from the Obstetrics Department, Obstetrics and Gynecology Hospital, Ain-Shams University. The study was conducted during the period from October 2010 to January 2011. All mothers were subjected to complete history taking, physical examination, laboratory investigations which included, maternal blood lead level, cord blood lead level and cord serum IGF-1. Statistical analysis was done to evaluate the different studied parameters. The mean maternal blood lead level was (10.9ug/dl) with a range of (2-19ug/dl), and the mean cord blood lead level was (2.08ug/dl) with a range of (0-5ug/dl). Our results revealed that, lead concentration in the umbilical cord was highly significantly correlated with the concentration of maternal venous blood lead (r= 0.665, P=0) but, there was no correlation between cord blood lead level and cord serum IGF-1 (r= -0.076, p=0.599). There were no statistically significant differences between cord blood lead levels and neonatal anthropometric parameters. Furthermore, in our study the cord serum IGF-1 was significantly correlated with birth weight of the newborns (r=0.322, p=0.023) but, had no correlation with other anthropometric parameters. |