الفهرس 
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Abstract
The aim of our study was to evaluate whether ovarian follicular phase of patients with unexplained recurrent spontaneous abortions is defective or not, serum levels of inhibin B during ovarian follicular phase was measured.
This prospective case control study was conducted at Ain Shams University Maternity Hospital.
The study included 70 women who were divided into 2 groups: Group 1: included 35 patients with ≥ 3 spontaneous abortions attending recurrent abortion clinic. Group 2: included 35 parous women with regular menstrual cycles and without any history of pregnancy loss attending gynecologic outpatient clinic serving as our control.
Our inclusion criteria were age 20-40 years, ≥3 spontaneous abortions for study group and regular menstrual cycles, no prior pregnancy loss and proven fertility by having one or more living child for control group. And our exclusion criteria were Polycystic ovarian disease ,decreased ovarian reserve ,anti-phospholipids antibody syndrome and other thrombophilic disorders., structural defects including cervical incompetence ,thyroid gland abnormalities , hyperprolactinemia. , diabetes mellitus and known genetic disease in either parent. Every subject was subjected to: verbal consent, detailed history to ensure our inclusion criteria, withdrawal of a venous blood sample to assess: day 2 level of :( inhibin B by an ELISA technique, FSH, LH, E2), complete blood count, PT and PTT, Fasting and 2 hours postprandial blood glucose levels, prolactin, T3, T4, TSH, anticardiolipin antibodies (IgG and IgM) and Lupus anticoagulant.
Statistical comparison between both groups showed non significant statistical difference regarding the age, Hb, WBCs, PLT, PT, and PTT, TSH, FT3, FT4, BMI, FSH, LH, E2, prolactin, progesterone and antiphospholipids antibodies (LAC, ACA IgG, IgM).Also regarding our results inhibin B had no significant statistical difference between both groups.
According to our correlation study there was no significant positive correlation between inhibin B and these variables (age, PLT, PT, PTT, FT4, LH, FSH, prolactin, and lupus anticoagulant) and there was no significant negative correlation between inhibin B and these variables (Hb, FBS, PPBS, FT3, TSH, E2, progesterone, and anticardiolipin IgG, IgM) also there was significant negative correlation beween inhibin B and WBCs.
In conclusion we found that ovarian follicular phase of patients with unexplained recurrent spontaneous abortions is not defective, by measureing serum levels of inhibin B during ovarian follicular phase for these patients.