الفهرس 
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Abstract
6-SUMMARY
The study was carried out on Faculty of Agriculture at
Moshtohor rabbit farm and the laboratory work was done in
Animal Production Research Institute, Agricultural Research
Center, Ministry of Agriculture, Egypt. The Field work was
carried out during the period from February till July 2002.
The present study was planned to investigate the productive
and reproductive performance traits of rabbits as toxic by
copper oxychloride fungicide and more effecting on general
healthy and effects on chromosomal aberrations. Using 45
New Zealand White (NZW) mature rabbit females. Their
aging ranged between 5-6 months and weight average about
3 kg. Feed and water provided ad.libtum for two weeks
before experiment starting, after that were assigned to three
groups experimental according to the following lethality
copper oxychloride doses.
1stgroupiGj ) = Basal feed (control).
2ngroup(G2) =Feeding for mixture copper oxychlorid
(0.1184 gm eu/Kg. BW/day)as 1/20LD50·
3rd group (G 3) = Feeding for mixture copper oxychloride
(0.2368 gm Cu ika. BW/day) as 1/10 LD 50’
The results obtained in this study could be summarized as
follows:
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SUMMARY
I-Feed intake:
Daily feed consumption were recorded from the
beginning experiment till slaughtering to obtained the
samples, the result observed decreased of feed intake for 2n d
by (18.05%) and 3 rd groups by (42.4%) compared with
control group respectively.
2_Clinical symptoms:
Rabbits were under observation daily for evidence of
clinical signs as general depression, loss of appetite.
excessive thirst. soft feces. dark and brown urine and easily
detached hair.
3._Hematological analysis:
Hemoglobin (Hb) concentrations were 11.78,9.33 and
8.12 gm/ 100 ml in the 1”. 2nd alla”’rd groups respectively
after 60 days. These results decreased significantly (P<0.05).
The means ofPCV% were 39.16.32.93 and 29.03 0A
st 2 d ”rd for 1 ,n and groups. The results were decreased
significantly (P<O.OOl).
The highest of mean value for RBCs was 5.96
millions/mm 3 in the 1 st group, while the lowest value was
2.96 millions/mm ’ in the 3rd group after 60 days for
treatment.
The highest of mean value for WBCs was 7.81
thousand/ mm 3 in the 1 st group, while the lowest value was
3.95 thousand/ mm ’ in the 3 rd group after 60 days. These
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SUMMARY
results were decreased significantly (P<O.OOl),that due to
the effect of treatment.
4-Biochemical analysis:
For analysis enzymes AST and ALT to refer for liver
functions, from obtained results, the highest mean value of
AST was 69.47 un in the 3rd group, while the lowest value
was 16.68U/l in the l s’ group.
The highest mean value of ALT enzyme was 84.99
un in the 3,,1group, while the lowest of value was 16.48
un. The obtained results were increased significantly
(P<O.OOl) in liver enzymes, that due to the effect of
treatment.
Creatinine concentrations in serum were increased
significantly (P<O.OO1) between groups at different exposed
periods. But urea concentrations in serum were not
significantly differences among groups.
For determination copper element residues. the
highest mean values were 376.69 in serum, 73.70 in liver,
50.53 in kidney, 9.80 in muscle 271.10 in feces and 1.17 in
urine in the 3 rd group. These results were increased
significant (P<O.OOl) among group after 60 days of
experiment. In this cases the liver and kidney must be
removal from rabbit carcass.
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5-Histopatholo~ical chan~es:
Liver was observed hydropic degeneration of
hepatocytes in 2 nd group after 40 days from beginning
SUMMARY
experiment, while in the 3rd group after 40 days, showing
extensive hydropic degeneration of hepatocytes and
congestion of central veins.
Kidney samples histopathological examined, showing
cloudy swelling of the lining epithelium of renal convoluted
tubules for both treated groups compared with control group.
In both treated groups (2nd and 3rd) the ovaries
examined, showing degeneration and atrasia of some ovarian
follicles.
In each of treated groups, uterine hom examined and
showing congestion of the uterine blood vessels (2nd group)
and hyperplasia of the lining epithelium of endometrium (3 rd
group).
6-Reproductive and productive performance:
Ovary weight, oviduct length and number of corpora
lutea were not significantly differences between groups. But
number of embryos per hom was decreased significantly
(P<O.05) in treated groups.
The mean values of number for implantation sites per
female were 8.33, 7.50 and 6.80 in the Is t, 2nd, and 31d group
respectively, these results decreased significantly (P<0.05)
between groups. The percentage of post-implantation loss
were 3.92, 9.96 and 29.68 % in the Is \ 2nd and 3rd groups
respectively, these results were increased significant
(P<0.05). The obtained results due to the effect of copper
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SUMMARY
oxychioride fungicide overload and advanced exposed
rabbits.
The means of litter size at birth were 7.25, 5.75 and
5.25 in the 1St,2nd and group respectively, these results
decreased significant (P<0.05) after 60 days. Also, the mean
values for litter size at weaning (28 days) were 6.25, 4.00 and
2.75 in the 1’, ~~ and 3 rd groups respectively, that results
decreased significant (P<O.OOl). The obtained results due to
the effect of treatment throughout lactation periods.
The means of litter weight at birth and weaning were
decreased significant (P<O.OOl)in the treated groups.
The percentages of pre-weaning mortality were
13.8%,30.4% and 47.6% in the 1’,2” and 3rd groups
respectively. from the results, the highest of mean value was
in the 3rd group that due to the effect of treatment, lead to
poisoning of the offspring rabbits.
I_Cytogenetic study:
In the present study the results indicated that effect of
copper oxychioride fungicide on the structural aberration
chromosome in rabbits were increased significantly (P<O.Ol)
in both treated groups compared with control group.
Gaps. deletions, and sticky structure aberrations were
significantly (P<O.OOI) in both treated groups, while
centromeric attenuations and ring structures were
significantly (P<O.O1).