الفهرس 
RetinoidsOnly 14 pages are availabe for public view
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Abstract
Oral premalignant lesions (OPL) include leukoplakia, erythroplakia, dysplastic leukoplakia, dysplastic lichenoid lesion, oral submucous fibrosis, and lichen planus . Oral premalignant lesions have shown a rate of progression of up to 17% within a mean period of 7 years after diagnosis. Retinoids and interferons (IFNs); used as biochemoprevention therapy have single-agent activity and synergistic combined effect in modulating cell proliferation, differentiation, and apoptosis in vitro and clinical activity in vivo in the head and neck and other sites. Alterations in the p53 protein resulting in its accumulation in cells may play a critical role in tumorigenesis ,including premalignant lesions and cancers of the head and neck region i.e. p53 protein status is a predictor of progression of premalignant oral dysplasia to invasive cancer.
Subjects and methods: Fifteen patients having oral premalignant lesions expressing mild to moderate signs of dysplasia; diagnosed both clinically and with H&E, were given treatment in the form of isotretinoin (Vitamin A) and interferon α for three months, and the levels of expression of p53 protein were examined by immunohistochemistry pre-& post treatment.
Results: The mean value of optical staining density of P53in pre treatment specimen was (59.78 ± 10.22) compared to (39.74 ± 3.36) in after treatment cases; this value was higher in before treatment cases than after treament cases. The p value was 0.0003.Thus when statistically compared the difference is considered statistically significant.
Conclusion: Biochemopreventive therapy in the form of two-drug combination ( INFα and 13-cis-retinoic acid) Reiferon®, and Isotretinoin® appeares to be highly active in advanced oral premalignant lesions.