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العنوان
ROLE OF SERUM INHIBIN-B AS PREDICTOR OF OVARIAN OUTCOME AFTER LONG PROTOCOL OF INDUCTION
المؤلف
Tawfek,Rasha Ahmed
هيئة الاعداد
باحث / Rasha Ahmed Tawfek
مشرف / Maher Abdel-Razik
مشرف / Amr Abed El Aziz El
الموضوع
SERUM INHIBIN-B AS -
تاريخ النشر
2010
عدد الصفحات
194.p:
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
أمراض النساء والتوليد
تاريخ الإجازة
1/1/2010
مكان الإجازة
جامعة عين شمس - كلية الطب - Obstetrics and gynecology
الفهرس
Only 14 pages are availabe for public view

from 194

from 194

Abstract

Assisted reproduction treatments are expensive, time-consuming and stressful for patients. A major challenge to the assisted-reproduction treatment teams is to predict prospectively patients who will be low responders and to counsel appropriately women who are potential candidates for assisted reproduction treatment (Ficicioglu et al., 2003).
Over the past two decades, a number of Ovarian Reserve Tests (ORTs) have been designed to determine oocyte reserve and quality and have been evaluated for their ability to predict the outcome of IVF in terms of oocyte yield and occurrence of pregnancy (Kan et al., 2006).
Many of the ovarian reserve tests have become part of the routine diagnostic procedure for infertility patients who undergo assisted reproductive techniques. The unifying goals are traditionally to find out how a patient will respond to stimulation and what their chances of pregnancy are (Kan et al., 2006).
The aim of this study is to explore the value of serum inhibin-B measurement in predicting ovarian response in infertile patients undergoing controlled ovarian hyperstimulation (COH) for in vitro fertilization (IVF) cycle.
This prospective study included 40 patients who complaining of infertility due to variable etiology, which was undergoing ICSI treatment in the assisted reproductive unit at Ain Shams University Maternity Hospital. Age of included women ranged between 30-40 years old (mean 31.8 years ±4.5). Duration of infertility of ranged between 2-16 (mean 6.4 years ±3.7). Serum sample was taken from included women at day 3 of non stimulated cycle for detecting serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin hormone, thyroid releasing hormone (TSH), and Inhibin B hormone. TVS was performed to all included women on the same cycle day for recording the antral follicle count (AFC) (defined as number of follicles measuring 2-8 mm at cycle day 3). After induction of ovulation during IVF cycle, oocytes were retrieved, IVF was done, and number of embryos available for transfer was counted.
All women included in the study, starting long protocol treatment for ICSI were randomly selected. Certain exclusion criteria were respected in these patients PCOs, patients receiving hormonal therapy within 3 months of the hormonal assay and azospermic males in need of testicular biopsy.
The results of this prospective study were tabulated and statistically correlated where it documented that there were positive correlation between AFC, inhibin B and number of oocyte retrieved.