الفهرس 
WHO classification of lymphoid neoplasmsOnly 14 pages are availabe for public view
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Abstract
Chronic lymphocytic leukemia (CLL) is a neoplastic disorder characterized by accumulation of small ,mature lymphocytes in the bone marrow (BM), peripheral blood, and lymphoid tissues. The clinical presentation, course and outcome are extremely heterogeneous. At presentation most patients are asymptomatic; up to 25% are diagnosed when routine blood work reveals an absolute lymphocytosis. Clinical symptom is in the form of painless, intermittent swelling of lymph nodes. In 5-10% of patients, clinical presentation consists of B symptoms, which include unintentional weight loss >10% within the previous six months, fevers >38ºC for >2 weeks without evidence of infection, drenaching night sweats without evidence of infection, or extreme fatigue. Other clinical findings consist of autoimmune hemolytic anemia or thrombocytopenia, recurrent infections, splenomegaly, hepatomegaly, or, rarely, extranodal infiltrates.several biomarkers have been suggested as potential prognostic factors in CLL. These include the mutational status of the immunoglobulin heavy variable (IGHV) genes and certain recurrent genomic aberrations.